1-Boc-4-[(methylamino)methyl]piperidine

1-Boc-4-[(methylamino)methyl]piperidine - Names and Identifiers

Name	4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms	1-Boc-4-[(Methylamino)methyl]piperidine 1-Boc-4-[(methylamino)methyl]piperidine 1-N-BOC-4-[(METHYLAMINO)METHYL]PIPERIDINE 1-piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1 TERT-BUTYL 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLATE 4-[(METHYLAMINO)METHYL]PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperidinecarboxylic acid, 4-[(methylamino)methyl]-, 1,1-dimethylethyl ester
CAS	138022-02-3
InChI	InChI=1/C12H24N2O2/c1-12(2,3)16-11(15)14-7-5-10(6-8-14)9-13-4/h10,13H,5-9H2,1-4H3

1-Boc-4-[(methylamino)methyl]piperidine - Physico-chemical Properties

Molecular Formula	C12H24N2O2
Molar Mass	228.33
Density	0.988
Boling Point	301.0±15.0 °C(Predicted)
Flash Point	135.829°C
Vapor Presure	0.001mmHg at 25°C
pKa	10.41±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.469
MDL	MFCD06656629

1-Boc-4-[(methylamino)methyl]piperidine - Risk and Safety

Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29333990

1-Boc-4-[(methylamino)methyl]piperidine - Introduction

4-[(methylamino) methyl] piperidine-1-carboxylic acid tert-butyl ester, also known as MTBD, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless liquid.
-Molecular formula: C13H23NO2.
-Molecular weight: 225.33g/mol.
-Boiling point: 108-110 degrees Celsius.
-Density: 0.997g/cm³.

Use:
- MTBD is often used as a base catalyst in organic synthesis, especially in esterification, acylation and electrophilic substitution reactions. It can promote the reaction rate and improve the yield.
-It is also commonly used as a fixed substrate catalyst, an additive for Ruthenium catalysts, a surfactant and a lubricant.

Preparation Method:
Tert-butyl 4-[(methylamino) methyl] piperidine-1-carboxylate can be obtained by reacting MTBD with formic anhydride. The specific preparation method can refer to literature and patent.

Safety Information:
- MTBD is irritating and corrosive, and contact with skin and eyes may cause inflammation and pain, so direct contact should be avoided during operation. If contact occurs, rinse immediately with water.
-During use and storage, attention should be paid to fire and explosion-proof measures. Avoid contact with strong oxidants and strong acids.
- MTBD should be operated in a well-ventilated place to avoid inhalation of its vapors.
-Observe local laws and regulations when handling or disposing of MTBD.

Please follow existing safety procedures when using and handling MTBD, and refer to relevant safety data sheets and technical literature.

Last Update：2024-04-10 22:29:15